Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease)

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Abstract
A 62‐year‐old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of bilary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper‐responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found.