Should Nonsteroidal Anti-inflammatory Drugs Be Stopped Before Elective Surgery?
- 1 October 1991
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 151 (10) , 1963-1966
- https://doi.org/10.1001/archinte.1991.00400100049008
Abstract
Purpose.— To determine if perioperative use of nonsteroidal anti-inflammatory drugs (NSAIDs) might be associated with increased postoperative morbidity. Patients and Methods.— Records from 165 patients undergoing total hip arthroplasty from 1984 to 1987 were reviewed. Patients taking NSAIDs at hospital admission were compared with those who were not. Results.— Patients taking NSAIDs had more postoperative bleeding complications (gastrointestinal tract bleeding and/or hypotension) than did patients not taking those agents. Complications were more frequent in patients using NSAIDs with half-lives longer than 6 hours. Conclusion.— Patients undergoing elective surgery should stop taking NSAIDs in time to allow elimination of the drug; those patients who need to take these agents perioperatively should use drugs with short half-lives. (Arch Intern Med. 1991;151:1963-1966)Keywords
This publication has 1 reference indexed in Scilit:
- The post-mortem incidence of pulmonary embolism in a hospital populationBritish Journal of Surgery, 1968