Antitrypanosomal Activity of Sinefungin
- 1 January 1983
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 32 (1) , 31-33
- https://doi.org/10.4269/ajtmh.1983.32.31
Abstract
Sinefungin, a naturally occurring antifungal antibiotic nucleoside containing an ornithine residue, linked by a C-C bond to C-5′ of adenosine, cures mice infected with Trypanosoma brucei brucei, T. congolense, or T. vivax; the effect of the drug is more pronounced towards T. congolense. Anti-trypanosomal activity of sinefungin could be the result of the inhibition of transmethylation reactions or of polyamine biosynthesis—or both—in parasites.This publication has 0 references indexed in Scilit: