TRANSMISSION AND SCANNING ELECTRON MICROSCOPIC OBSERVATIONS OF MOUSE ADRENOCORTICAL ADENOMA CELLS (Y‐1) IN NON‐STIMULATED AND STIMULATED STATES

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Abstract
ACTH sensitive murine adrenocortical adenoma cells (Y-1) were examined by transmission and scanning electron microscopy under nonstimulated and stimulated conditions. They showed the ultrastructural characteristics which were different from those of the original adrenocortical cells of LAF1 mice. The smooth-surfaced endoplasmic reticulum (sER) were poorly developed, and the mitochondrial cristae showed lamellar rather than tubular or tubulovesicular type. Administration of ACTH induced rounding-up of the Y-1 cells with a slight increase in sER, but no mitochondria with vesicular inner structure appeared. The effects of dbcAMP [dibutyryl cyclic AMP] on the morphology of the Y-1 cells were similar to those of ACTH except that the rounding-up occurred more rapidly and uniformly.