Safe Method of Collecting Leukaemia Cells from Patients with Acute Leukaemia for Use as Immunotherapy
- 16 November 1974
- Vol. 4 (5941) , 375-379
- https://doi.org/10.1136/bmj.4.5941.375
Abstract
Leukaemia cells were collected from the blood of 72 untreated patients using a continuous-flow blood cell separator. The yield of cells was proportional to the number circulating in the patient, and up to 1 × 1012 could be obtained in three hours. Complications of the procedure were mild, consisting of chills and shivering in 18% of patients. Leucopheresis at the time of diagnosis is an essential part of setting up a specific immunotherapy programme for patients with acute myelogenous leukaemia, and the lack of harmful side effects makes the collection of these cells ethically justified. The need for a centralized service to provide cells for this form of therapy is emphasized.Keywords
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