ORAL-ADMINISTRATION OF CHYMOTRYPSIN LABILE PEPTIDE FOR A NEW TEST OF EXOCRINE PANCREATIC FUNCTION (PFT) IN COMPARISON WITH PANCREOZYMIN-SECRETIN TEST

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 69  (5) , 572-578
Abstract
A new test using N-benzoyl-L-tyrosyl-p-aminobenzoic acid (N-BT-PABA) for an evaluation of exocrine pancreatic function was compared with a pancreozymin-secretin test in 38 subjects. Urinary recovery of PABA [para-aminobenzoic acid], which is absorbed from the intestine and conjugated in the liver after an oral administration of N-BT-PABA, depends mainly on chymotrypsin activity. The recovery rate of PABA in urine decreases in chronic pancreatitis, in which chymotrypsin activity in the duodenal juice is disturbed. The recovery rate of PABA in calcifying chronic pancreatitis was 40.2 .+-. 15% and significantly less than 81.2 .+-. 7.4% in normal subjects (P < 0.01). The amount of PABA in urine during 8 h was correlated with parameters of volume output, bicarbonate concentration and amylase output stimulated by injections of pancreozymin and secretin (P-S test). The new test using N-BT-PABA is useful for the evaluation of exocrine pancreatic function in general practice.

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