New Directions in the Biology and Therapy of Chronic Myeloid Leukemia
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Leukemia & Lymphoma
- Vol. 6 (2) , 89-95
- https://doi.org/10.3109/10428199209064884
Abstract
Great excitement surrounded the initial discovery of the Philadelphia chromosome translocation and the molecular rearrangement of the abl protooncogene which is generated by this translocation in chronic myelogenous leukemia (CML). In this review, we will discuss how molecular analysis of the biological abnormalities generated in the CML cells by this molecular rearrangement can be applied to new directions in therapy for this disease.Keywords
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