The Structure and Function of Telomerase Reverse Transcriptase
Top Cited Papers
- 1 June 2006
- journal article
- review article
- Published by Annual Reviews in Annual Review of Biochemistry
- Vol. 75 (1) , 493-517
- https://doi.org/10.1146/annurev.biochem.75.103004.142412
Abstract
The structure and integrity of telomeres are essential for genome stability. Telomere dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The maintenance ...Keywords
This publication has 185 references indexed in Scilit:
- DNA-Protein Kinase Catalytic Subunit-interacting Protein KIP Binds Telomerase by Interacting with Human Telomerase Reverse TranscriptaseJournal of Biological Chemistry, 2004
- Telomerase activity level, but not hTERT mRNA and hTR level, regulates telomere length in telomerase-reconstituted primary fibroblastsExperimental Cell Research, 2004
- Human Telomerase Reverse Transcriptase Motifs Required for Elongation of a Telomeric SubstratePublished by Elsevier ,2003
- Telomere maintenance and DNA replication: how closely are these two connected?Trends in Genetics, 2003
- Conserved N-terminal Motifs of Telomerase Reverse Transcriptase Required for Ribonucleoprotein Assembly in VivoJournal of Biological Chemistry, 2003
- The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase InhibitorCell, 2001
- Clonal Variation in Phenotype and Life Span of Human Embryonic Fibroblasts (MRC-5) Transduced with the Catalytic Component of Telomerase (hTERT)Experimental Cell Research, 2001
- Stable Association of hsp90 and p23, but Not hsp70, with Active Human TelomeraseJournal of Biological Chemistry, 2001
- Mass Cultured Human Fibroblasts Overexpressing hTERT Encounter a Growth Crisis Following an Extended Period of ProliferationExperimental Cell Research, 2000
- A theory of marginotomyJournal of Theoretical Biology, 1973