The Biochemistry and Clinical Application of Vitamin P

Abstract
THE term vitamin P was proposed by Armentano and his co-workers1 to denote a group of compounds distinct from ascorbic acid that maintained the physical strength of capillaries. This concept grew out of investigations to determine why crude sources of vitamin C controlled hemorrhages in vascular purpura whereas purified ascorbic acid was ineffective. From the ascorbic-acid-free residue of the mother substance, a faintly yellow crystalline material, which was found to exert the so-called vitamin P activity, was extracted. Because of its derivation from citrus fruits, this active powder was called citrin. Various analyses revealed that citrin was a mixture of . . .
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