Effect of N-3-(4-hydroxyphenyl)propionyl Pro-Pro-Gly-Ala-Gly on calcium-induced arrhythmias.
- 1 January 1988
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 36 (11) , 4597-4599
- https://doi.org/10.1248/cpb.36.4597
Abstract
The present investigation was done to examine whether or not the presence of hydroxyproline in N-3-(4-hydroxyphenyl) propionyl Pro-Hyp-Gly-Ala-Gly (HP-5) is essential for the antiarrhythmic activity. Pretreatment of mice with 10 mg/kg of [Pro2]-HP-5 provided significantly better protection against calcium-induced arrhythmias than did pretreatment with HP-5. Thus, the prolyl residue was more favorable than the hydroxyprolyl residue for antiarrhythmic activity of these analogues.Keywords
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