Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-α-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial
- 1 January 1985
- journal article
- case report
- Published by Oxford University Press (OUP)
- Vol. 79 (5) , 692-698
- https://doi.org/10.1016/0035-9203(85)90195-6
Abstract
Difluoromethylornithine (DFMO), a specific, irreversible inhibitor of polyamine biosynthesis shown to be curative in animal models inoculated with varKeywords
This publication has 14 references indexed in Scilit:
- Chemotherapeutic implications of polyamine biosynthesis inhibitionClinical Pharmacology & Therapeutics, 1984
- Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.Journal of Clinical Oncology, 1984
- Arsenic and old taxa: subspeciation and drug sensitivity in Trypanosoma bruceiTransactions of the Royal Society of Tropical Medicine and Hygiene, 1984
- Brain, CSF, and tumor pharmacokinetics of ?-difluoromethylornithine in rats and dogsCancer Chemotherapy and Pharmacology, 1983
- In vivo effects of α-dl-Difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei bruceiMolecular and Biochemical Parasitology, 1983
- Antagonism by polyamines of the curative effects of α-difluoromethylornithine in Trypanosoma brucei brucei infectionsBiochemical Pharmacology, 1981
- The six diseases WHO. Human trypanosomiasis in Africa.BMJ, 1981
- Kinetics of α-difluoromethylornithine: An irreversible inhibitor of ornithine decarboxylaseClinical Pharmacology & Therapeutics, 1981
- Present status of chemotherapy and chemoprohylaxis of human trypanosomiasis in the Eastern HemispherePharmacology & Therapeutics, 1980
- IgM and Antibody Measurement in the Diagnosis and Management of Gambian TrypanosomiasisThe American Journal of Tropical Medicine and Hygiene, 1977