Three Times Daily or 8-Hourly
- 1 January 1986
- journal article
- Published by SAGE Publications in Journal of the Royal Society of Medicine
- Vol. 79 (1) , 15-16
- https://doi.org/10.1177/014107688607900105
Abstract
The timing of drug ingestion over 24 hours was assessed in 58 outpatients taking drugs three times daily. The mean time between 1st and 2nd dose was 5.7 hours, 2nd and 3rd 6.1 hours and between 3rd and 1st of the next day 12.2 hours. Based on a simulation of hydralazine pharmacokinetics, such irregular administration would increase peak levels by 10% and decrease trough levels by 64% compared with regular 8-hourly doses.Keywords
This publication has 6 references indexed in Scilit:
- Slow release beta-adrenoceptor blocking drugs.1983
- Treatment of hypertension. Comparative trial of metoprolol Durules (once daily) and metoprolol tablets (twice daily).1982
- Plasma levels and negative chronotropic effect of metoprolol following single doses of a conventional and sustained-release formulationEuropean Journal of Clinical Pharmacology, 1979
- Clinical Pharmacokinetics of HydrallazineClinical Pharmacokinetics, 1977
- Drug Defaulting in a General PracticeBMJ, 1969