Epstein‐barr virus (EBV)‐induced lymphoproliferative disease in cotton‐topped marmosets

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Abstract
Six cotton‐topped marmoset monkeys (Sangiunus oedipus) were inoculated with 105 tranforming units of B95‐8 virus, and two of them developed fatal lymphoproliferative disease. The EBV‐carrying tumor cells from these marmosets had the following characteristics: (I) they were polyclonal by surface immunoglobulin and immunoglobulin production in vitro; (2) they had no specific chromosome abnormalities, and (3) they failed to form colonies in large percentages in agarose. It is proposed that a spectrum of phenotypes of EBV‐induced lympho‐proliferative diseases in the cotton‐topped marmosets may be identified and are more akin to fatal infectious mononucleosis or X‐linked lymphoproliferative syndrome than to Burkitt's lymphoma.