Bullatencin, 4‐deoxyasimicin, and the uvariamicins: Additional bioactive annonaceous acetogenins from Annona bullata rich. (Annonaceae)

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Abstract
Additional bioactive Annonaceous acetogenins have been isolated from the EtOH extract of the bark of Annona bullata Rich. by bioactivity-directed fractionation using lethality to brine shrimp. These acetogenins include bullatencin, a new single tetrahydrofuran acetogenin having a double bond in the hydrocarbon chain; 4-deoxyasimicin, a new adjacent bis-tetrahydrofuran acetogenin; and the uvariamicins, an isomeric mixture of four single tetrahydrofuran acetogenins. These acetogenins showed selective cytotoxicities for certain human solid tumor cell lines comparable to or better than adriamycin.