Cardiac Nucleotides and Derivatives in Acute and Chronic Ventricular Failure of the Dog Heart

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Abstract
The levels and proportionate distribution of nucleotides, nucleosides, and bases were determined in myocardial samples from two freshly excised hearts, three acutely failing left ventricle preparations in which the nonworking right ventricle served as control, and two hearts from dogs in which aortic regurgitation was produced surgically as a source of chronic overload of the left ventricle. Ventricular performance was evaluated from cardiac function studies, including measurements of cardiac output, stroke work, and contractility. The compounds identified by chromatographic resolutions were AMP, ADP, ATP, DPN, UPP, and GPP; inosine and hypoxanthine; and uridine and uracil. Qnantitative analyses revealed no consistent difference in specific composition of nonfailing and acutely or chronically failing ventricles.

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