Mechanisms of Exercise Intolerance

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Abstract
Background— A decreased ratio of early to late diastolic mitral inflow velocities (E/A Methods and Results— Patients (n=121) underwent echocardiography before maximal exercise testing. Fifty-nine subjects had E/A r=−0.684, PPConclusions— Of the subjects with slow LV relaxation, only those with E/Ea ≥10 have objective evidence of reduced exercise tolerance. These data suggest that elevated LV filling pressures rather than slow relaxation per se reduce exercise capacity.

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