A New Principle for Prevention of Diarrhoea Caused by Enterotoxigenic Escherichia Coli (ETEC) Possessing Colonization Factor Antigen (CFA/I)

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Abstract
The infant rabbit model, developed to study human ETEC [enterototoxin-producing E. coli] with CFA/I [colonization factor antigen], was used to evaluate agarose gel substituted with a hydrophobic ligand for pervention of diarrheal symptoms. In a group of rabbits given 0.02 g of palmitoyl Sepharose 1 h after an oral infection with 109 ETEC organisms with CFA/I antigen, only 2/11 animals developed diarrhea; in the control groups given the unsubstituted Sepharose (hydrophilic) gel or ETEC organisms alone, all animals developed diarrhea. In groups of rabbits given the hydrophobic gel 6 h after the ETEC organisms, 2/6 animals showed a short period of diarrhea.