Two Epimeric Dibromo Nitriles From the Australian Sponge Aplysina laevis
- 1 January 1987
- journal article
- research article
- Published by CSIRO Publishing in Australian Journal of Chemistry
- Vol. 40 (2) , 341-346
- https://doi.org/10.1071/ch9870341
Abstract
Two dibromo nitriles, (1′R,5′S,6′S)-2-(3′,5′-dibromo-1′,6′-dihydroxy-4′-oxocyclohex-2′- enyl) acetonitrile (5) and the (l′R,5′R,6′S) epimer (6), possessing antimicrobial activity, have been isolated from the sponge Aplysina laevis (Carter). Cometabolites (+)-aeroplysinin-1 (1) and the dibromo ketone (2) were also identified. Structures (5) and (6) were assigned on the basis of spectroscopic evidence and synthesis from (1).Keywords
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- Exudation of biologically-active metabolites in the sponge Aplysina fistularisMarine Biology, 1985
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