PRP gene variability in the us cattle population
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Animal Biotechnology
- Vol. 3 (2) , 309-315
- https://doi.org/10.1080/10495399209525779
Abstract
The primary amino acid sequence of the prion protein (PrP) has previously been correlated with changes in the incubation period of subacute spongiform encephalopathies. We have analyzed the PrP gene from 65 different cattle representing 14 breeds by polymerase chain reaction and restriction enzyme analysis. Two distinct PrP alleles differing in the number of octapeptide repeats are present. The predominant genotype is homozygous for 6 octapeptide repeats. Few individuals (8) were found to be heterozygous for these repeats and only 1 animal was homozygous for the 5 octapeptide repeat allele.Keywords
This publication has 11 references indexed in Scilit:
- Different Forms of the Bovine PrP Gene have Five or Six Copies of a Short, G-C-rich Element within the Protein-coding ExonJournal of General Virology, 1991
- Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion ProteinScience, 1990
- Two alleles of a neural protein gene linked to scrapie in sheep.Proceedings of the National Academy of Sciences, 1990
- An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob diseaseMolecular Brain Research, 1990
- Pro→Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndromeBiochemical and Biophysical Research Communications, 1989
- Linkage of a prion protein missense variant to Gerstmann–Sträussler syndromeNature, 1989
- Distinct prion proteins in short and long scrapie incubation period miceCell, 1987
- Isolation of a cDNA clone encoding the leader peptide of prion protein and expression of the homologous gene in various tissues.Proceedings of the National Academy of Sciences, 1986
- Molecular cloning and complete sequence of prion protein cDNA from mouse brain infected with the scrapie agent.Proceedings of the National Academy of Sciences, 1986
- Molecular Cloning of a Human Prion Protein cDNADNA, 1986