Long-Term Effect of Intravenous Calcitriol on the Treatment of Severe Hyperparathyroidism, Parathyroid Gland Mass and Bone Mineral Density in Haemodialysis Patients

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Abstract
We conducted this study on 15 chronic haemodialysis patients to evaluate the efficacy of i.v. calcitriol over a 1-year period in the treatment of severe secondary hyperparathyroidism (HPT), in particular its effect on bone mineral density (BMD) and parathyroid gland mass. Mean age was 39 ± 11.9 (20-65) years and dialysis duration was 58 ± 3 (19-130) months, i.v. calcitriol was given at a dose of 1 µg post-dialysis 3 times/week for 3 weeks; the dose was then adjusted to maintain the total serum calcium at less than 2.88 mmol/l. The maximum dose was 3 µg 3 times/week. Serum calcium (Ca) and phosphorus (P) were determined prior to treatment, then weekly for 6 weeks and every 2 weeks thereafter. Skeletal survey, dual photon densitometry and parathyroid ultrasound (US) were done prior to treatment and after 1 year. Bone biopsy was done in 10 patients at the beginning of treatment. There was a significant reduction (p 2 (p 2 (p

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