Radioimmunoimaging of venous thrombi using iodine-131 monoclonal antibody.

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Abstract
Murine monoclonal antibody (Mab) specific for the NH2-terminal region of human fibrin, but not cross-reactive with fibrinogen, was used in radioimmunoimaging of fresh, induced venous thrombi in 3 dogs. 131I-labeled Mab was injected i.v. with 125I-labeled polyclonal murine .gamma.-G globulin (IgG) simultaneously injected as a control. Images were strongly positive at 24 and 48 h in all 3 animals, with thrombus-to-blood and thrombus-to-muscle ratios of 8.4 and 228.0, respectively, for 131I-labeled Mab; these ratios for control IgG were 1.2 and 13.0. Radioimmunodetection of thrombi in vivo is feasible in dogs and may have clinical application since Mab is specific to human fibrin.

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