Highly Enantioselective Catalytic Hetero-Diels-Alder Reaction with Inverse Electron Demand
- 18 September 1998
- journal article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 37 (17) , 2404-2406
- https://doi.org/10.1002/(sici)1521-3773(19980918)37:17<2404::aid-anie2404>3.0.co;2-d
Abstract
Valuable substrates for the synthesis of natural products, compounds 3 (R1=alkyl, aryl, alkoxy; R2, R3=alkyl) are formed from β,γ‐unsaturated α‐keto esters 1 and vinyl ethers 2 by the title reaction [Eq. (1)]. Copper(II) bisoxazolines act as catalysts, and in many cases enantiomeric excesses higher than 99.5 % are achieved.Keywords
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