Comparison of Laser in situ Keratomileusis and Photorefractive Keratectomy for the Correction of Myopia of -6.00 Diopters or Less

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Abstract
PURPOSE: To evaluate the safety and efficacy of laser in situ keratomileusis (LASIK) compared to photorefractive keratectomy (PRK) for the correction of low or moderate myopia (-0.50 to -6.00 D) at 6 months after surgery. METHODS: The study population comprised a non-randomized consecutive series of 622 eyes of 392 patients who were treated with the Nidek EC-5000 excimer laser. LASER was performed using the ACS Chiron microkeratome on 314 eyes and surface PRK on 308 eyes. All patients were treated using a standard protocol, then assessed at 1, 3, and 6 months postoperatively. RESULTS: Forty-four percent of the LASIK group and 67% of the PRK group attended their 6-month examination. Eighty percent of patients (111 eyes) after LASEK and 65% (136 eyes) after PRK had an uncorrected visual acuity of 20/20 or better. Spherical equivalent refraction was within ±0.50 D of intended refraction in 78% (109 eyes) for LASEK and 82% (170 eyes) for PRK. Loss of two more lines of best spectacle-corrected visual acuity at 6 months occurred in 1.4% (2 eyes) of the LASEK group and 1.0% (2 eyes) of the PRK group. CONCLUSION: At 1 month follow-up, the percentage of eyes that achieved 20/20 uncorrected visual acuity was greater in the LASEK group than in the PRK group. At 6 months, visual and refractive outcomes of LASEK and PRK were similar. Although flap related complications occurred only after LASEK, the overall risk of loss of best spectacle-corrected visual acuity was not significantly greater than for PRK. [J Refract Surg 2001;17:46-54]