Testosterone-Induced Depression of Adrenergic Activity in the Perfused Canine Hindlimb

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Abstract
Twenty-four hours after a single dose of testosterone proprionate (10 mg/kg im) the responses of the perfused canine hindlimb preparation to intra-arterial injections of tyramine, angiotensin and acetylcholine were significantly reduced when compared with the responses of control animals receiving peanut oil (0.1 ml/kg ip). The response of the hindlimb to bilateral carotid occlusion was also reduced in these animals. The pressor response to intra-arterial norepinephrine and the vasodepressor response of active reflex vasodilatation in response to intravenous norepinephrine were equivocal in the animals receiving testosterone or vehicle. It was concluded that 24 hr after a single dose of testosterone the sensitivity of the canine hindlimb vasculature to the vasoactive agents tested was depressed. Alterations in adrenergic neuronal catecholamine content or stabilization of the nerve terminal membrane together with increased cholinesterase activity may have contributed to the depression of adrenergic function and the antagonism of the vasodepressor response to acetylcholine in testosterone-treated animals.

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