Studies on the Efficiency of Vitamin K1 in Small Doses as Antidote Against Anticoagulants of the Dicoumarol Type

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Abstract
Doses of about 10-20 mg of vitamin K1 given intravenously in the form of a sterile aqueous colloidal solution are recommended as a means of raising the procon-vertin-prothrombin value in cases where treatment with Dicoumarol anticoagulants has resulted in serious hemorrhage. In this way a therapeutic effect is obtained within 2 hours, whereas oral administration acts more slowly. Higher doses are unnecessary and dangerous by favoring thrombosis. Treatment with menadione and its simpler derivatives is considered of no value because of the low and uncertain efficiency of these compounds in counteracting the hypoprothrombinemia caused by Dicoumarol anticoagulants.