HUMAN IA-LIKE ANTIGENS IN NON-LYMPHOID ORGANS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 38  (2) , 333-341
Abstract
An immunofluorescence assay showed that human Ia-like antigens [Ag] in liver and kidney were present mostly in the endothelial-mesenchymal cells of these organs. The parenchymal cells apparently contained no human Ia-like Ag. The Ag in liver and kidney were purified and had the same subunit structure as human Ia-like Ag of cultured B [bone marrow-derived] lymphoid cells. The human Ia-like Ag in non-lymphoid organs, i.e., liver, kidney, testis, heart, muscle and brain, carried all the xenoantigenic characteristics of human Ia-like Ag expressed on lymphoid cells of B cell lineage.