THE EFFECT OF THYROXINE ON THE EXTENT OF REGENERATION IN THE ENUCLEATED ADRENAL GLAND OF THE RAT

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Abstract
In expts. with 23 pairs of unilaterally adrenalectomized rats it was found that when one adrenal is present and the other enucleated, the adm. of thyroxine causes an extensive cortical proliferation in the intact gland; histologically there is an increase in the extent of zona glomerulosa in the enucleated gland on treated animals with an intact right adrenal; there is no significant difference between the wts. of the enucleated glands of treated and control animals. When one adrenal is removed, the extent of regeneration in the enucleated gland of thyroxine-treated animals exceeds by far the extent in enucleated glands of untreated controls.

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