Toxicity Studies on Dibutyl- and Diamyl-Hydroquinone

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Abstract
Two hydroquinone derivatives, 2,5-di-tert-butylhydroquinone and 2,5-di-tert-amylhydroquinone, have been suggested as antioxidants to protect carotene of dehydrated alfalfa meal. Neither compound modified growth, appearance, organ weights or histological structure of rats eating diets containing as much as 0.2% of antioxidants for 500 days. No symptoms of intoxication developed in exploratory tests on rats when single doses of 1500 mg/kg of compounds were given by stomach tube. These materials did not sensitize the skin of guinea pigs but did produce a reversible lesion on rabbit and guinea pig skin when applied daily to the skin as 10% solutions in cottonseed oil.

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