STUDIES ON INORGANIC SALT METABOLISM IN DOGS

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Abstract
Studies on mineral metabolism in puppies were made. The diets were (1) basal, (2) basal diet with a P-free salt mixture added, (3) basal diet and salt mixture supplemented with K2HPO4. "Metabolism and blood studies indicate that the seat of the disturbance in faulty'' mineral metabolism is in the tissues rather than the gastrointestinal tract." Calcification depends on 2 factors: (1) the metabolic state inherent in the individual (the more important); (2) diet. Precipitation of bone salts is determined by the balance of ions between the bone-forming cells and the surrounding medium, and any agent (diet, hygiene, ultraviolet light, active principle in cod liver oil, etc.) which either directly or by catalysis influences the metabolism of the bone cells will alter that balance and become an important factor in regulating the deposition and resorption of bone. A theory of the mechanism of calcification is given.

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