Does the Urinary Excretion of Imidazole Acetic Acid Reflect the Endogenous Histamine Metabolism in Man?

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Abstract
Dunér H., S. O. Liljedahl B. Pernow. Does the urinary excretion of imidazole acetic acid reflect the endogenous histamine mtabolism in man?The urinary excretion of free and conjugated histamine, histidine and imidazole acetic acid (ImAA) was studied in four healthy subjects and four patients with severe burns. ImAA was found to be a normal constituent of human urine. In the cases of burn, where the histamine excretion was increased during the first days after the accident, the ImAA excretion was normal and showed no significant variations. Administration of histamine or histidine gave a slight increase in the excretion of ImAA.

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