AN ISOTOPIC STUDY OF OXALATE EXCRETION IN SHEEP

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Abstract
Summary: Intravenously injected 14C labelled oxalate was rapidly removed from the blood stream via the kidney in 2 sheep, 75% being cleared within 8 h. Mean daily urinary oxalate excretions over 5 days were 21·2 and 27·5 mg and the derived plasma oxalate concentrations were 52·6 and 74·4 μg/100 ml, respectively. Oxalate was both filtered and secreted by the renal tubule with oxalate/inulin ratios varying from 1·11 to 1·57 in 6 normal sheep. A large increase in calcium excretion induced by calcium borogluconate infusion over 5 days was accompanied by a small but consistent increase in urinary oxalate excretion relative to calcium.Oxalate in blood was to be found mainly in the plasma, there being a small (8%) proportion within erythrocytes. This is lower than that reported for man, and yet in its excretion of oxalate via the kidney the sheep appears to closely resemble man and dog.