Increased Drug Effect Induced by Surgery
- 1 October 1982
- journal article
- research article
- Published by SAGE Publications in Human Toxicology
- Vol. 1 (4) , 447-449
- https://doi.org/10.1177/096032718200100412
Abstract
1 A thyrotoxic patient receiving a constant dose of propranolol and digoxin developed marked bradycardia postoperatively. 2 Compared to preoperative levels there was a considerable rise postoperatively in both plasma propranolol and serum digoxin steady-state concentrations. 3 Surgery by effecting drug disposition and disease processes may significantly alter drug handling in the perioperative period.Keywords
This publication has 4 references indexed in Scilit:
- Influence of Thyroid Dysfunction on Drug PharmacokineticsClinical Pharmacokinetics, 1981
- Influence of surgery on plasma propranolol levels and protein bindingClinical Pharmacology & Therapeutics, 1980
- Effect of surgery under general anaesthesia on antipyrine clearance.Published by Wiley ,1978
- Increased plasma binding of quinidine after surgery: A preliminary reportEuropean Journal of Clinical Pharmacology, 1976