Sexual Differentiation and Testosterone Production

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Abstract
Since the number of genes characterizing mammalian species is approximately 50 to 100 X 103, it would be reasonable to assume that mammalian sex determination and differentiation involve either directly or indirectly thousands of genes. Yet these numerous genes cannot be left alone to go their separate ways. They should be controlled by a series of genetic regulatory systems that constitute an orderly hierarchy. This orderliness, I believe, is the hallmark of higher organisms.Viewed in this light from the top of a hierarchy, the genetic basis of the mammalian sex-determining mechanism, in which the Y chromosome plays the . . .