Rating the presence and severity of opiate dependence

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Abstract
The means for rating dependence to narcotic drugs and determining the severity of physical dependence is examined, using the administration at 0.8 mg naloxone intramuscularly and assessing the severity of dependence mainly by the presence and time of appearance of withdrawal signs. Responses were studied in 75 patients with drug abuse problems. Naloxone or saline was administered double blind and at random. In methadone‐ and opiate‐dependent sub;ects, net withdrawal scores after naloxone differed significantly from those after saline. In nonopiate‐dependent patients, there was no significant difference between net scores after naloxone and after saline. The results at the investigation were confirmed by a crossover study in which naloxone and saline were administered to 4 patients with suspected opiate dependence.

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