Clinical implications for immunoscintigraphy in patients with ovarian malignancy: a preliminary study using monoclonal antibody 791T/36

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Abstract
Twelve patients with suspected primary and recurrent carcinoma of the ovary have undergone immunoscintigraphy with an antitumor monoclonal antibody to assess the impact of the technique on patient management. Consistent tumor uptake of radiolabeled antibody was visualized in malignant tumors after subtraction of the blood background activity. Eight patients were imaged before surgery and in all of these the sites of uptake visualized on the images agreed with the surgical findings. In 1 patient with recurrent disease the imaging information was used as an aid for establishing the extent of external beam radiotherapy. A repeat study in this patient 6 mo. later revealed a reduction in the size of the tumor, which still concentrated labeled antibody and confirmed the viability of repeat investigations. Immunoscintigraphy was capable of providing diagnostic information which may offer an alternative to 2nd-look surgery in these patients.