AGE AND NATURE OF OPERATION INFLUENCE THE PHARMACOKINETICS OF MIDAZOLAM
- 1 September 1985
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 57 (9) , 866-871
- https://doi.org/10.1093/bja/57.9.866
Abstract
The pharmacokinetics of midazolam were studied in surgical patients given 0.3 mg kg-1 i.v. for either the induction of anaesthesia, or post-operative sedation following cardiopulmonary bypass. The short elimination half-life of midazolam (2.4 h in patients < 50 yr undergoing minor surgery) was significantly, although not markedly, prolonged with age (4.1 h in patients > 50 yr undergoing minor procedures) and by the nature of the operation (3.8 h after major operative procedures). These changes were the result of alterations in clearance and volume of distribution with age, and in volume of distribution with nature of operation.This publication has 6 references indexed in Scilit:
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