Synthesis of a Pondaplin Dimer and Trimer. Aromatic Interactions in Novel Macrocycles
- 25 February 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in The Journal of Organic Chemistry
- Vol. 69 (7) , 2526-2531
- https://doi.org/10.1021/jo0356006
Abstract
Synthetic challenges in the use of an oxabicyclo[2.2.2]octenone moiety as a masked arene for the synthesis of pondaplin are disclosed. During the course of a study of the Heck reaction as a tool for macrocyclization to provide strained paracyclophanes, novel macrocycles displaying intra- and intermolecular aromatic interactions have been synthesized. The geometry of these interactions is compared to recent computational literature data.Keywords
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