Response of Micropenis to Topical Testosterone and Gonadotropin

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Abstract
Patients [5] were treated with gonadotropin and topical testosterone for micropenis associated with hypothalamic hypogonadotropic hypogonadism. All patients received 1000 units of gonadotropin weekly for 3 wk, with a 6 wk interval followed by 10% topical testosterone cream twice daily for 3 wk. Serum testosterone levels were measured and remained equivalent for both modes of therapy. Average penile growth response with gonadotropin was 14.3% increase in length and 5.0% increase of girth. Topical testosterone produced an average increase of 60% in penile length and 52.9% in girth. Greatest growth response occurred in prepuberal male subjects with a minimal response in postpuberal male subjects. Apparently 10% topical testosterone cream twice daily will produce effective penile growth. The response appears to be greater in younger children, which is consistent with previously published studies of age-related 5 reductase activity.