ANTAGONISM OF THE RESPIRATORY EFFECTS OF ALFENTANIL AND FENTANYL BY NALOXONE IN THE CONSCIOUS RABBIT

Open Access

1 October 1981

journal article
research article
Published by Elsevier in British Journal of Anaesthesia

Vol. 53 (10) , 1033-1037
https://doi.org/10.1093/bja/53.10.1033

Abstract

The ability of naloxone to antagonize the respiratory effects of alfentanil, a new short-acting analgesic, was studied in the rabbit. The results were compared with naloxone antagonism of fentanyl. Minute volume and respiratory frequency, and pH, Pco₂ and standard bicarbonate of arterialized venous blood were measured. Naloxone was more effective as an antagonist to alfentanil than as an antagonist to fentanyl.

Keywords

ALFENTANIL
NALOXONE
ORYCTOLAGUS CUNICULUS
FENTANYL
ANTAGONISTS
RESPIRATORY RATE
ANALGESICS
BICARBONATE THERAPY
CARBON DIOXIDE

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