Enantiodivergent Route to the Aromatic Bisabolane Sesquiterpenes via a Chiral Acetylene Alcohol
- 1 October 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Chemistry Letters
- Vol. 18 (10) , 1781-1784
- https://doi.org/10.1246/cl.1989.1781
Abstract
Efficient preparation and practical utilization of (R)-1-benzyloxy-3-butyn-2-ol have been established. Treatment of (2S,3S)-4-benzyloxy-2,3-epoxybutyl chloride, obtained via the Sharpless epoxidation, with n-butyllithium afforded (R)-1-benzyloxy-3-butyn-2-ol which could be transformed enantiodivergently into the key synthetic intermediates of the aromatic bisabolane sesquiterpenes.Keywords
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