Effects of the characteristics of chitosan on controlling drug release of chitosan coated PLLA microspheres

1 January 2001

journal article
research article
Published by Taylor & Francis in Journal of Microencapsulation

Vol. 18 (5) , 613-625
https://doi.org/10.1080/02652040010019497

Abstract

Chitosan has been shown to be a biomaterial with good biocompatibility, and is highly biodegradable. This study investigated the effect of post-coating PLLA microspheres with different chitosans on the initial burst and controlling the drug release of the microspheres. Without chitosan, 19.2% of encapsulated lidocaine would release from PLLA microspheres within the first hour (R₁), and the time of 50% release (T₅₀

Keywords

CHITOSAN PLLA MICROSPHERE CONTROLLED DRUG RELEASE

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