A cytogenetic and cytophotometric analysis of resident and exudate murine macrophages

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Abstract
Cytogenetic analysis and Feulgen-DNA cytophotometry were performed on murine resident and exudate peritoneal macrophages. A large proportion (14-36%) or metaphase profiles from cell populations rich in resident macrophages displayed chromosomal aberrations compared with 0-8%, seen in metaphases from cell populations rich in exudate macrophages. The most common aberration observed was the presence of chromosomal gaps. If the resident macrophage represents a later or terminal stage of macrophage development, the high frequency of aberrations may be a result of cellular aging.