CD1-restricted T-cell responses and microbial infection
- 17 August 2000
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 406 (6797) , 788-792
- https://doi.org/10.1038/35021233
Abstract
CD1, a conserved family of major histocompatibility (MHC)-like glycoproteins in mammals, specializes in capturing lipid rather than peptide antigen for presentation to T lymphocytes. The principles and mechanisms of this newly discovered immune strategy differ markedly from those governing classical MHC–peptide presentation. They might be exploited for the design of new lipid-based microbial vaccines and adjuvants.Keywords
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