Immunostaining for cyclin D1 and the diagnosis of mantle cell lymphoma: is there a reliable method?

1 March 1999

journal article
research article
Published by Wiley in Histopathology

Vol. 34 (3) , 266-268
https://doi.org/10.1046/j.1365-2559.1999.00662.x

Abstract

Immunostaining for cyclin D1 has become essential for the reliable diagnosis of mantle cell lymphoma (MCL). MCL is associated with a poor prognosis and its distinction from other small B‐cell lymphomas is clinically important. However, many diagnostic laboratories report problems in finding a reliable method. The following articles by Chan and by Miller, Munson & Isaacson discuss the common problems and describe successful methods with advice on diagnostic interpretation.

Keywords

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