Inhibition of experimental oral carcinogenesis by topical beta carotene

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Abstract
β-Carotene was found to significantly inhibit the formation of 7, 12-dimethylbenz(a)anthracene (DMBA)-induced squamous cell carcinoma of hamster buccal pouch when applied topically on days alternate to the application of 0.25% DMBA in heavy mineral oil thrice weekly for 22 weeks. An initial experiment utilized 40 male young adult Syrian hamsters divided into four equal groups. Group 1 had DMBA applied to left buccal pouches thrice weekly. Group 2 had DMBA applied as in group 1 but also β-carotene thrice weekly on days alternate to the DMBA application of 0.25% DMBA in heavy mineral oil thrice weekly for 22 weeks. An initial experiment utilized 40 male young adult Syrian hamsters divided into four equal groups. Group 1 had DMBA applied to left buccal pouches thrice weekly. Group 2 had DMBA applied as in group 1 but also β carotene thrice weekly on days alternate to the DMBA application. Group 3 animals were painted with only β carotene and group 4 animals were untreated controls. In a second experiment with 80 animals, β carotene was found to inhibit oral carcinogenesis in an initiation-promotion hamster buccal pouch system using 0.1% DMBA as initiator and 40% benzoyl peroxide as promoter. β-Carotene inhibited both initiation and promotion.