SOME QUANTITATIVE STUDIES OF THE LOCALIZATION OF URANIUM IN THE PRINCIPAL ORGANS OF RABBITS DURING THE COURSE OF URANIUM INTOXICATION BY USE OF THE MAGNETO-OPTIC METHOD

31 August 1933

journal article
research article
Published by American Physiological Society in American Journal of Physiology-Legacy Content

Vol. 105 (3) , 693-696
https://doi.org/10.1152/ajplegacy.1933.105.3.693

Abstract

Known quantities of U nitrate were injected subcut. into the abdominal walls of fasted rabbits. The animals were sacrificed successively. The quantities of U found in the various organs of the body, blood, and urine of each animal were then determined quantitatively at definite intervals from 1 to 24 hrs. after injection. The magneto-optic method has been used to advantage in the quantitative determination of U in the blood, urine, kidney, spleen, urinary system, and liver and the results tabulated. No U was found in the bile or gall bladder. From 1 to 50% (ave. 20%) of the total U was found in the liver and from 6 to 39% (ave. 23%) in the kidney. U is excreted through the kidney during the first 24 hrs. and not through the bile. None of the metal was found in a control animal.

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