MODELLING OF LACTIC ACID PRODUCTION BY STREPTOCOCCUS CREMORIS HP

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Abstract
A mechanistic mathematical model is developed for S. cremoris HP which uses the intracellular substrate [lactose] concentration as a variable for the fermentation system. The concept of a threshold intracellular substrate concentration and a new model of product inhibition are introduced to account for a pronounced lag phase and a strong metabolic product inhibitory effect. Parameters for the model are determined from experimental data from 7 batch runs with widely varying initial and final conditions. Statistical tests and comparisons with another model are carried out. A possible method of optimization is discussed in terms of the developed model.

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