Reversible Pathologic Jealousy (Othello Syndrome) Associated With Amantadine

Abstract
We describe a case of pathologic jealousy (Othello syndrome) in a patient with Parkinson disease, which abated after discontinuing amantadine. We indicate that early recognition and treatment of the syndrome in this disease may avert physical violence. We also believe that our report further suggests a link between this specific behavioral disorder and dopaminergic activity. (J Geriatr Psychiatry Neurol 1991;4:157-159).