Late Effects on the Eye of Conformation Radiotherapy for Carcinoma of the Paranasal Sinuses and Nasal Cavity

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Abstract
Patients (60) with carcinoma of the paranasal sinuses and nasal cavity were treated with conformation radiotherapy technique (an improved moving-field technique). Only 28 were suitable for long-term follow-up with regard to eye complications. All patients receiving more than 5800 rads in 6 wk (1700 R in cumulative-radiation-effect dose) had strong panophthalmia with corneal ulceration within 2 yr of radiotherapy. Of 21 eyes receiving 800-1700 R (2800-5400 rads in 6 wk), 18 experienced visual disturbance from radiation cataracts and 3 equivocal changes at postirradiation intervals of 5 yr. No patient receiving less than 800 R (2800 rads in 6 wk) showed such complications.

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