Human Glomerular Basement Membrane: Chemical Alteration in Diabetes Mellitus
- 1 May 1970
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3931) , 596-598
- https://doi.org/10.1126/science.168.3931.596
Abstract
The human glomerular basement membrane belongs to the collagen family of proteins. It contains about 7 percent carbohydrate, half of which occurs as glucosylgalactose disaccharide units linked to hydroxylysine. Glomeruli from diabetics contain increased amounts of basement membrane material. In addition, these membranes show a distict chemical alteration c haracterized by a significant decrease in lysine, accoumpanied by an equivalent increase in hydroxylysine and hydroxylysine-linked disaccharide units.Keywords
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